Program

（Updated on 2008-06-16）

The 3^rd ISN Special Neurochemistry Conference

8^th International Meeting on Brain Energy Metabolism –

“Neurodegeneration and Regeneration”

Beijing China

June 27 - July 1, 2008

www.isnbeijing2008.org

Program

***** FRIDAY, JUNE 27, 2008 *****

12:00-18:30

Registration

18:30-19:15

Keynote Speech: Mary C. McKenna ( USA )

Changing concepts in brain energy metabolism

K-1

Chair:

YU Albert C. H. (China)

19:15-22:00

Reception

***** SATURDAY, JUNE 28, 2008 *****

Session I

Glucose and Lactate as Substrate in Neurotransmission

Chairs:

CHEN Jian Guo (China)

Gerald A. Dienel (USA)

8:00-8:25

Gerald A. Dienel (USA)

Astrocyte activation and capacity for metabolite trafficking during brain activation

S-01

8:25 - 8:50

H. Ronald Zielke (USA)

In vivo oxidation studies in the living rat brain studied by microdialysis – effect of fluorocitrate

S-02

8:50 - 9:15

Luc Pellerin (Switzerland)

Regulation of expression and distribution of monocarboxylate transporters in neurons and glia

S-03

9:15 - 9:40

Sebastian Cerdan (Spain)

The role of subcellular compartmentation of monocarboxylates and glutamate in the redox exchange between neurons and astrocytes in vivo and in vitro

S-04

9:40 - 10:05

Break

Session II

Glycogen in Brain

Chairs:

WU Bing Yi (China)

Bruce R. Ransom (USA)

10:05 - 10:30

Bernd Hamprecht (Germany)

Neural function of glycogen

S-05

10:30 - 10:55

Helle S. Waagepetersen (Denmark)

Glycogen metabolism: significance and functional impact

S-06

10:55 - 11:20

Rolf Gruetter (Switzerland)

New approaches to and insights into glucose, glycogen, glutamate and glutamine metabolism in brain

S-07

11:20 - 11:45

Marie E. Gibbs (Australia)

Essential role for glycogen in memory processing

S-08

11:45 -14:00

Lunch and Poster Session

Session III

Imaging and NMR Studies of Brain Metabolism or Neurotransmitter Synthesis and Metabolism Studies by NMR

Chairs:

CUI De Hua (China)

Ursula Sonnewald (Norway)

14:00 - 14:25

Pierre-Gilles Henry (USA)

New approaches for metabolic modeling of ¹³C NMR data using two-compartment neuronal-glial models

S-09

14:25 - 14:50

Asta Haberg (Norway)

Metabolic changes in contralateral hemisphere and cerebellum in acute stroke and their possible implications in functional recovery

S-10

14:50 - 15:15

Jorge J. Riera (Japan)

The astrocytic networks participate in the functional hyperemia via metabolic waves induced and sustained by extracellular glutamate

S-11

15:15 - 15:40

Fahmeed Hyder (USA)

Energetics of neural signaling and fMRI activity

S-12

15:40 - 16:05

Kevin L. Behar (USA)

GABA synthesis and glial function: insights from NMR studies of rats and mutant mice

S-13

16:05 -16:30

Break

Session IV

Cellular and Subcellular Localization and Regulation of Metabolic Shuttle Mechanisms

Chairs:

CHEN Xiao Qian (China)

Kathryn F. LaNoue (USA)

16:30 - 16:55

Luis F. Barros (Chile)

Acute control of astrocytic glucose dynamics by neuronal signals: studies in vitro

S-14

16:55 - 17:20

Lasse K. Bak (Denmark)

Is neuronal utilization of glucose and lactate during neurotransmission governed by Ca²⁺-mediated modulation of cytosolic-mitochondrial NADH shuttling?

S-15

17:20 - 17:45

Katsuei Shibuki (Japan)

Transcranial flavoprotein fluorescence imaging of experience-dependent cortical plasticity

S-16

17:45 - 18:10

William C. Shuttleworth (USA)

Fluorescence imaging of mechanisms underlying spreading depression in hippocampal slices

S-17

18:10 - 18:35

Silvia Mangia (USA)

Human brain metabolism studied by 1H NMR spectroscopy

S-18

18:35-20:10

Dinner

20:10 - 22:10 Student Data Blitz

Chairs:

Leif Hertz (China)

Mary C. McKenna (USA)

Presenters:

*1. Silje Alvestad (Norway*)	*7. Helle Mark Sickmann (Denmark)*
*2. Ana Isabel Amaral (Portugal)*	*8. Sun Fengbo (China)*
*3. Elizabeth Beauchesne (Canada)*	*9. Ruud B. Van Heeswijk (Switzerland)*
*4. Dong Yan (China)*	*10. Anne Byriel Walls (Denmark)*
*5. Gu Li (China)*	*11. Zhu Lei (China)*
*6. Ying Jin (Ireland)*

***** SUNDAY, JUNE 29, 2008 *****

8:00 - 8:45

Keynote Speech: Philip G. Haydon (USA)

Astrocytic purines regulate sleep homeostasis and memory loss following sleep deprivation

K-2

Chair:

Arne Schousboe (Denmark)

Session V

Tripartite Synapse and Receptor Mediated Metabolism

Chairs:

WANG Yun (China)

Vladimir J. Balcar (Australia)

8:45 - 9:10

Caroline Rae (Australia)

Understanding your inhibitions: metabolomic analyses of the GABAergic system

S-19

9:10 - 9:35

Vladimir Parpura (USA)

Spatio-temporal characteristics of exocytosis in astrocytes

S-20

9:35 - 10:00

Philip J. Robinson (Australia)

Dynamin inhibitors reduce synaptic transmission and are novel anti-epileptic drugs

S-21

10:00-10:25

Break

Session VI Mitochondrial Function and Dysfunction (I)

Chairs:

WAN You (China)

Ursula Sonnewald (Norway)

10:25 - 10:50

Gary E. Gibson (USA)

Specific abnormalities in mitochondrial enzymes are crucial in the pathophysiology of neurodegenerative disorders

S-22

10:50 - 11:15

Neil R. Sims (Australia)

Mitochondrial glutathione and neural cell susceptibility to disease

S-23

11:15 - 11:40

Simon J. Heales (UK)

to be added

Glutathione, mitochondrial function and neurodegeneration

S-24

11:40

Great Wall Tour and Free Evening in the City of Beijing (Details will be announced during the conference)

***** MONDAY, JUNE 30, 2008 *****

Session VII Mitochondrial Function and Dysfunction (II)

Chairs:

LAU Lok Ting (China)

Rolf Gruetter (Switzerland)

8:00 - 8:25

Vera Adam-Vizi (Hungary)

Regulation of reactive oxygen species generation by calcium

S-25

8:25 - 8:50

Ian J. Reynolds (USA)

Mitochondrial dynamics in neurodegeneration

S-26

8:50 - 9:15

Pak H. Chan (USA)

Oxidative stress and mitochondrial dysfunction as determinants in ischemic neuronal death and survival

S-27

9:15 - 9:40

Xiongwei Zhu (USA)

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

S-28

9:40 - 10:05

Philip M. Beart (Australia)

Proapoptotic mitochondrial signalling and the commitment to die: insult-dependent actions of neurologic stressors

S-29

10:05-10:30

Break

Session VIlI

Microglia and Oligodendrocytes in Neurodegeneration

Chairs:

XU Xian Hao (China)

Jean de Vellis (USA)

10:30 - 10:55

Monica J. Carson ( USA )

Defining the molecular tipping points between neuroprotective and neurodestructive responses in microglia

S-30

10:55 - 11:20

Jaime Grutzendler(USA)

In vivo imaging of microglia reveals a prominent neuroprotective role in Alzheimer's disease

S-31

11:20 - 11:45

Bruce R. Ransom (USA)

Ischemic injury of oligodendrocytes in CNS white matter

S-32

11:45-14:00

Lunch and Poster Session

Session IX Ammonia Metabolism and Toxicity

Chairs:

ZHAO Ji Zong (China)

Roger F. Butterworth (Canada)

14:00 - 14:25

Michael D. Norenberg (USA)

Signaling mechanisms in ammonia neurotoxicity

S-33

14:25 - 14:50

Claudia Zwingmann (Canada)

Cell-specific metabolism in acute and chronic hyperammonemia: multinuclear NMR studies in animal- and cell culture models

S-34

14:50 - 15:15

Susanne Keiding (Denmark)

Reduced cerebral blood flow and oxygen consumption in cirrhosis patients with acute hepatic encephalopathy

S-35

15:15 - 15:40

Jan Albrecht (Poland)

Cyclic GMP and ammonia neurotoxicity

S-36

15:40-16:05

Break

Session X Metabolic Underpinnings of Epilepsy

Chairs:

JIANG Yu Wu (China)

Helle S. Waagepetersen (Denmark)

16:05 - 16:30

Steve H. White (USA)

Modulating non-GAT1 GABA transporters for the treatment of epilepsy and other CNS disorders

S-37

16:30 - 16:55

Astrid Nehlig (France)

Efficacy of the ketogenic diet in epilepsy: clinical and experimental data

S-38

16:55 - 17:20

Torun M. Melø (Norway)

to be added

Neuronal glial interactions in an animal model of childhood absence epilepsy

S-39

17:20 - 17:45

Tomoyuki Kanamatsu (Japan)

Changes in the rates of the TCA cycle and glutamine synthesis in the brain with neurological disorder: studied by in vivo ¹³C nuclear magnetic resonance spectroscopy

S-40